Volume 6, Issue 1 (Avicenna Journal of Pharmaceutical Research, Jun 2025)
Avicenna J Pharma Res 2025, 6(1): 47-58 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Keshvari-Sharif O, Vafaie S Y, Haddadi R, Pourmoslemi S. Development and Toxicity Assessment of a Nano-Niosomal Preparation for Topical Delivery of Azelaic Acid. , Avicenna J Pharma Res. 2025; 6 (1) :47-58
URL: http://ajpr.umsha.ac.ir/article-1-113-en.html
URL: http://ajpr.umsha.ac.ir/article-1-113-en.html
1- Department of Pharmaceutics, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Pharmacology and Toxicology, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
2- Department of Pharmacology and Toxicology, School of Pharmacy, Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract: (19 Views)
Background: The present study aimed to design and investigate a topical preparation based on niosomal nanocarriers for local delivery of azelaic acid.
Methods: Niosomal nanocarriers were prepared using a thin-layer hydration method. Physicochemical properties of nanocarriers, including size and morphology, zeta potential, and drug entrapment efficiency, were determined. A hydrogel containing the nano-niosomes was prepared and investigated for viscosity, pH, release, and ex vivo skin permeability of azelaic acid. Rabbit skin irritation and cell cytotoxicity of the preparations were investigated using Draize and MTT tests, respectively.
Results: Azelaic acid containing niosomal nanocarriers were prepared in the form of homogeneous spherical vesicles, with 274.3 nm size, and +46.1 mV zeta potential. Azelaic acid entrapment efficiency was 95.1% ± 3.8%, and niosomal nanocarriers were stable at 4 and 25 °C for 3 months. The hydrogel released 89.6 ± 3.48% of azelaic acid in 24 h, and skin permeation was 77.9 ± 4.9 μg/cm2. Toxicological investigations did not show any skin irritation or cell cytotoxicity.
Conclusion: The prepared topical preparation based on niosomal nanocarriers can be a promising approach for the local delivery of azelaic acid. It showed good physicochemical properties, sustained release, and increased skin permeation of azelaic acid, without causing any side effects.
Methods: Niosomal nanocarriers were prepared using a thin-layer hydration method. Physicochemical properties of nanocarriers, including size and morphology, zeta potential, and drug entrapment efficiency, were determined. A hydrogel containing the nano-niosomes was prepared and investigated for viscosity, pH, release, and ex vivo skin permeability of azelaic acid. Rabbit skin irritation and cell cytotoxicity of the preparations were investigated using Draize and MTT tests, respectively.
Results: Azelaic acid containing niosomal nanocarriers were prepared in the form of homogeneous spherical vesicles, with 274.3 nm size, and +46.1 mV zeta potential. Azelaic acid entrapment efficiency was 95.1% ± 3.8%, and niosomal nanocarriers were stable at 4 and 25 °C for 3 months. The hydrogel released 89.6 ± 3.48% of azelaic acid in 24 h, and skin permeation was 77.9 ± 4.9 μg/cm2. Toxicological investigations did not show any skin irritation or cell cytotoxicity.
Conclusion: The prepared topical preparation based on niosomal nanocarriers can be a promising approach for the local delivery of azelaic acid. It showed good physicochemical properties, sustained release, and increased skin permeation of azelaic acid, without causing any side effects.
Type of Study: Research |
Subject:
Special
Received: 2026/10/31 | Accepted: 2025/09/1 | Published: 2026/10/31
Received: 2026/10/31 | Accepted: 2025/09/1 | Published: 2026/10/31
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
