Avicenna Journal of Pharmaceutical Research
Avicenna Journal of Pharmaceutical Research
Avicenna J Pharma Res
Medical Sciences
http://ajpr.umsha.ac.ir
1
admin
2717-1884
10.53208
en
jalali
1404
6
1
gregorian
2025
9
1
6
1
online
1
fulltext
en
Development and Toxicity Assessment of a Nano-Niosomal Preparation for Topical Delivery of Azelaic Acid
تخصصي
Special
پژوهشي
Research
<span style="font-size:12pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-0.2pt"><strong style="font-weight:normal"><b><span style="font-size:10.0pt"><span style="line-height:115%"><span style="color:black">Background:</span></span></span></b></strong><span style="font-size:10.0pt"><span style="line-height:115%"><span style="color:black"> The present study aimed to design and investigate a topical preparation based on niosomal nanocarriers for local delivery of azelaic acid.</span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-0.2pt"><strong style="font-weight:normal"><b><span style="font-size:10.0pt"><span style="line-height:115%"><span style="color:black">Methods:</span></span></span></b></strong><span style="font-size:10.0pt"><span style="line-height:115%"><span style="color:black"> Niosomal nanocarriers were prepared using a thin-layer hydration method. Physicochemical properties of nanocarriers, including size and morphology, zeta potential, and drug entrapment efficiency, were determined. A hydrogel containing the nano-niosomes was prepared and investigated for viscosity, pH, release, and <i>ex vivo</i> skin permeability of azelaic acid. Rabbit skin irritation and cell cytotoxicity of the preparations were investigated using Draize and MTT tests, respectively. </span></span></span></span></span></span></span><br>
<span style="font-size:12pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:-0.2pt"><strong style="font-weight:normal"><b><span style="font-size:10.0pt"><span style="line-height:115%"><span style="color:black">Results:</span></span></span></b></strong><span style="font-size:10.0pt"><span style="line-height:115%"><span style="color:black"> Azelaic acid containing niosomal nanocarriers were prepared in the form of homogeneous spherical vesicles, with 274.3 nm size, and +46.1 mV zeta potential. Azelaic acid entrapment efficiency was 95.1% ± 3.8%, and niosomal nanocarriers were stable at 4 and 25 °C for 3 months. The hydrogel released 89.6 ± 3.48% of azelaic acid in 24 h, and skin permeation was 77.9 ± 4.9 μg/cm<sup>2</sup>. Toxicological investigations did not show any skin irritation or cell cytotoxicity.</span></span></span></span></span></span></span><br>
<span style="font-size:10pt"><span style="line-height:115%"><span style="font-family:"Times New Roman","serif""><span style="letter-spacing:0pt"><strong style="font-weight:normal"><b><span style="color:black">Conclusion:</span></b></strong><strong style="font-weight:normal"><span style="color:black"> The prepared topical preparation based on </span></strong><span style="color:black">niosomal nanocarriers can be a promising approach for the local delivery of azelaic acid. It showed good physicochemical properties, sustained release, and increased skin permeation of azelaic acid, without causing any side effects.</span></span></span></span></span><br>
Azelaic acid, Hydrogel, Niosomal nanocarriers, Topical delivery
47
58
http://ajpr.umsha.ac.ir/browse.php?a_code=A-10-2-85&slc_lang=en&sid=1
Omid
Keshvari-Sharif