Avicenna Journal of Pharmaceutical Research

Background: Dhatupaushtik Churna is a polyherbal powdered formulation that contains equal amounts of Gokhru (Tribulus terrestris L.; Family: Zygophyllaceae), Ashwagandha (Withania somnifera L.; Family: Solanaceae), and Safed musli (Chlorophytum borivilianum L.; Family: Asparagaceae). It is used to treat a myriad of ailments, including premature ejaculation, weakness, rejuvenation of the male reproductive system, and anti-aging. This study aimed to thoroughly investigate this Churna using the Ayurvedic Pharmacopoeia of India’s (API’s) criteria.

Methods: The fundamental aspiration of this investigation is to document Dhatupaushtik Churna’s distinctive characteristics to legitimize its identification, quality, and purity. The innumerable specifications explored in this study included organoleptic characteristics, physicochemical parameters, physical characteristics of Churna, preliminary phytochemical, heavy metal, microbial analysis, metabolomic tracking using gas chromatography/mass spectrometry, and high-performance thin-layer chromatography assessment.

Results: It was revealed that the established parameters are informative tools for assisting regulatory authorities, scientific organizations, and manufacturers in developing high-efficacy standard formulations and can be utilized as reference standards in a pharmaceutical startup’s quality control/quality assurance laboratory.

Conclusion: Based on the findings, every ingredient in Dhatupaushtik Churna might be identified. The characterization parameters documented in this dissertation might be employed as a standard benchmark for the quality control analysis of Dhatupaushtik Churna. To uphold batch-to-batch consistency, the criteria given in this study might be used to prepare a monograph on quality standards for Dhatupaushtik Churna.