Volume 1, Issue 2 (Avicenna Journal of Pharmaceutical Research, Dec 2021)                   Avicenna J Pharma Res 2021, 1(2): 60-64 | Back to browse issues page

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Zargar N, J Nasiri M, Ashraf H, Hajikhani B, Etminani Esfahani S, Etminani Esfahani M. Antimicrobial Susceptibility of Enterococcus faecalis Isolated From Root Canal: An In Vitro Study. Avicenna J Pharma Res 2021; 1 (2) :60-64
URL: http://ajpr1.umsha.ac.ir/article-1-54-en.html
Antimicrobial Susceptibility of Enterococcus faecalis Isolated From Root Canal: An In Vitro Study
Nazanin Zargar1 , Mohammad J Nasiri2 , Hengameh Ashraf3 , Bahareh Hajikhani2 , Shirin Etminani Esfahani *4 , Maryam Etminani Esfahani5
1- Iranian Center for Endodontic Research, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Department of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Department of Endodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
4- School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Department of Clinical Pharmacy (Pharmacotherapy), School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract:   (24 Views)

Background: One of the major causes of failure in root canal treatment is microorganisms like Enterococcus faecalis.

Methods: This study aimed to examine the effectiveness of triple antibiotic paste (TAP) containing ciprofloxacin, metronidazole, and minocycline in comparison with modified TAP (MTAP) containing metronidazole, ciprofloxacin, and clindamycin and calcium hydroxide on Enterococcus strains isolated from root canal of tooth associated with pre-apical lesion. Moreover, we evaluated the E. faecalis resistance and antibiotic susceptibility. To do so, 25 patients with previous failure of endodontic treatment were enrolled in this study.

Results: The antimicrobial effect of MTAP10%, MTAP1%, TAP10%, TAP1%, and CaOH was significantly better than the positive control group (P <0.05). There was no significant difference between antimicrobial effect of TAP1% and MTAP1%, and CaOH was the least effective one. The antimicrobial effect of TAP10% was significantly better than MTAP10% (P = 0.007). Out of 11 E. faecalis samples, 1 sample was resistant to MTAP1% and MTAP10%, though it was sensitive to other drugs; meanwhile, it showed the highest sensitivity to TAP10%.

Conclusion: TAP10% was the most effective choice followed by MTAP10%, but calcium hydroxide was not effective compared to other choices. Thus, MTAP might be a good choice for root canal medicament instead of TAP

Keywords: Drug susceptibility, Enterococcus faecalis, Modified triple antibiotic paste, Triple antibiotic paste
Full-Text [PDF 276 kb]   (11 Downloads)    
Type of Study: case report | Subject: General
Received: 2026/09/28 | Accepted: 2021/02/28 | Published: 2026/09/29
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