Volume 6, Issue 2 (Avicenna Journal of Pharmaceutical Research, Dec 2026)
Avicenna J Pharma Res 2026, 6(2): 133-143 |
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Shafiee A. Microneedle Technologies for Peripheral Nerve Regeneration and Wound Healing: Advances, Challenges, and Translational Prospects. , Avicenna J Pharma Res. 2026; 6 (2) :133-143
URL: http://ajpr.umsha.ac.ir/article-1-127-en.html
URL: http://ajpr.umsha.ac.ir/article-1-127-en.html
1 Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran & 2 Medicinal Plants and Natural Products Research Center, Hamadan University of Medical Sciences, Hamadan, Iran
Abstract: (3 Views)
Background: Peripheral nerve injuries and neuropathy-associated chronic wounds remain difficult to treat because impaired axonal regeneration, persistent inflammation, oxidative stress, vascular dysfunction, and defective tissue repair frequently coexist.
Methods: This narrative review critically examines recent advances in microneedle (MN) technologies for peripheral nerve regeneration and chronic wound healing, with emphasis on platform design, biomaterials, therapeutic payloads, multifunctional systems, preclinical evaluation, and translational considerations.
Results: The reviewed literature highlights the development of dissolving, hydrogel-forming, biodegradable, conductive, responsive, and conduit-integrated MN systems capable of localized delivery and, in selected designs, electrical or piezoelectric stimulation. Therapeutic strategies include neurotrophic factors, extracellular vesicles, anti-inflammatory agents, nitric oxide/oxygen-generating systems, and electroactive components targeting neuro-immune-vascular dysfunction. Preclinical studies report improvements in wound closure, angiogenesis, inflammatory modulation, axonal regeneration, remyelination, and functional recovery; however, evidence remains dominated by rodent models, and direct peripheral nerve applications are less mature than wound-healing applications.
Conclusion: Overall, MN technologies represent promising multifunctional regenerative interfaces, while clinical translation remains constrained by manufacturing complexity, regulatory requirements, reproducibility, and limited validation in clinically relevant models.
Methods: This narrative review critically examines recent advances in microneedle (MN) technologies for peripheral nerve regeneration and chronic wound healing, with emphasis on platform design, biomaterials, therapeutic payloads, multifunctional systems, preclinical evaluation, and translational considerations.
Results: The reviewed literature highlights the development of dissolving, hydrogel-forming, biodegradable, conductive, responsive, and conduit-integrated MN systems capable of localized delivery and, in selected designs, electrical or piezoelectric stimulation. Therapeutic strategies include neurotrophic factors, extracellular vesicles, anti-inflammatory agents, nitric oxide/oxygen-generating systems, and electroactive components targeting neuro-immune-vascular dysfunction. Preclinical studies report improvements in wound closure, angiogenesis, inflammatory modulation, axonal regeneration, remyelination, and functional recovery; however, evidence remains dominated by rodent models, and direct peripheral nerve applications are less mature than wound-healing applications.
Conclusion: Overall, MN technologies represent promising multifunctional regenerative interfaces, while clinical translation remains constrained by manufacturing complexity, regulatory requirements, reproducibility, and limited validation in clinically relevant models.
Keywords: Diabetic wound healing, Microneedle drug delivery, Neurovascular regeneration, Peripheral nerve regeneration, Regenerative biomaterials, Schwann cell regeneration
Type of Study: Applicable |
Subject:
Special
Received: 2026/11/14 | Accepted: 2027/03/1 | Published: 2026/11/14
Received: 2026/11/14 | Accepted: 2027/03/1 | Published: 2026/11/14
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