en عمومى General پژوهشي Research <p><strong>Background:</strong> Inflammation is considered a highly important factor in the pathophysiology of ischemic stroke. Considering the neuroprotective and anti-inflammatory effects of calcitriol, its administration can be effective in reducing inflammation and ischemic stroke. Thus, this study amid to evaluate the modulatory effects of calcitriol on post-ischemic stroke inflammatory response.</p> <p><strong>Methods:</strong> This retrospective cohort study investigated 41 subjects who were diagnosed with acute ischemic stroke and were admitted to the neurology ward in the first 24 hours after the stroke. The exprimental group was given 1 &micro;g/day calcitriol for 3 consecutive days. C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured after taking blood samples immediately upon admission and after 72 hours.</p> <p><strong>Results:</strong> Our results revealed that CPR and ESR values were elevated after an ischemic stroke, while calcitriol could significantly (<em>P</em><0.05) diminish the ESR value after 72 hours.</p> <p><strong>Conclusion:</strong> Probably, due to its anti-inflammatory properties, calcitriol acts as protective reagent to reduce inflammation after ischemic stroke.</p> Calcitriol, Ischemic stroke, Inflammation, CPR, ESR 50 54 http://ajpr1.umsha.ac.ir/browse.php?a_code=A-10-2-14&slc_lang=en&sid=1 Mahdi Mahanpour 1003194753284600110 1003194753284600110 No Department of Clinical Pharmacy and Services, School of Pharmacy, Hamadan University of Medical Science, Hamadan, Iran Sara Ataei 1003194753284600111 1003194753284600111 No Department of Epidemiology, School of PublicHealth, Hamadan University of Medical Sciences, Hamadan, Iran Maryam Etminani Esfahani 1003194753284600112 1003194753284600112 No Department of Clinical Pharmacy and Services, School of Pharmacy, Hamadan University of Medical Science, Hamadan, Iran Salman Khazaei 1003194753284600113 1003194753284600113 No Department of Epidemiology, School of PublicHealth, Hamadan University of Medical Sciences, Hamadan, Iran Mojtaba Khazaei khazaeimojtaba@yahoo.com 1003194753284600114 1003194753284600114 Yes Department of Neurology, School of Medicine, Sina (Farshchian) Educational and Medical Center, Hamadan University of Medical Sciences, Hamadan, Iran