en عمومى General گزارش مورد case report <p><strong>Background</strong>: The objective of the present study was to design a porous osmotic pump-based drug delivery system for the controlled release of captopril (Cap) which can maintain a constant therapeutic concentration, thus reducing dose-related side effects and dosing frequency.</p> <p><strong>Methods</strong>: The study evaluated <em>in vitro</em> drug release for the controlled porosity osmotic pump tablet (CPOPT) of Cap. This <em>in vitro</em> drug release study investigated the influence of the tablet formulation variables such as the amount of mannitol, hydroxypropylmethylcellulose K4M (HPMCK4M), and polyvinyl pyrrolidone (PVP K-30) in the core and the concentration of cellulose acetate and polyethylene glycol 400 (PEG-400) in the coating solution.</p> <p><strong>Results</strong>: It was found that the drug release was mostly affected by the amount of mannitol, HPMCK4M, and PVP K-30 in the core and the amount of cellulose acetate and PEG-400 in the coating solution.</p> <p><strong>Conclusion</strong>: In general, the objective of the study was established by coating the core tablet containing osmotic and pore-forming agents. Therefore, the CPOPT of Cap could be a safe, effective, stable, and promising preparation in the future.</p> Captopril, Osmotic pump, Dissolution, Controlled release drug-delivery system, Swelling polymers 54 59 http://ajpr1.umsha.ac.ir/browse.php?a_code=A-10-2-32&slc_lang=en&sid=1 Paniz Mahjoub 1003194753284600183 1003194753284600183 No Department of Chemical Engineering, Hamadan University of Technology, Hamadan, Iran Amid Morshedlu Amorshedlu@ gmail.com 1003194753284600184 1003194753284600184 Yes Department of Mining Engineering, Technical University of Hamadan, Hamadan, Iran