en عمومى General پژوهشي Research <p><strong>Background</strong>: Self-nanoemulsifying drug delivery systems (SNEDDS) can be used to improve the oral bioavailability of lipophilic drugs. The aim of this study was the preparation and characterization of a SNEDDS for the oral delivery of budesonide as a poorly soluble drug.</p> <p><strong>Methods</strong>: To prepare SNEDDS, budesonide (20 mg) was dissolved in the mixture of liquid paraffin, Tween 80, and propylene glycol, followed by using the Box-Behnken response surface methodology for statistical optimization. The prepared mixtures were then diluted in the simulated intestinal fluid (SIF) and their physico-chemical characteristics were studied as well. Then, SNEDDS were morphologically evaluated using transmission electron microscopy (TEM). Finally, the <em>in vitro</em> release profile of budesonide from nano-droplets was determined in the SIF.</p> <p><strong>Results</strong>: Based on the results, the size, polydispersity index, zeta potential, and entrapment efficiency of statistically optimized SNEEDS were reported as 146&plusmn;37 nm, 0.211&plusmn;0.06, +3.6&plusmn;0.84 mV, and 94.3&plusmn;6.58%, respectively. In addition, TEM images revealed spherical nano-droplets. Further, the release profile of budesonide from nano-droplets exhibited 33.81&plusmn;1.67% of drug release in SIF during 360 minutes of incubation at 37&deg; C, indicating sustained drug release.</p> <p><strong>Conclusion</strong>: The obtained data demonstrated that SNEDDS could be regarded as a good candidate for oral delivery of budesonide as a poorly water-soluble drug representing a high first-pass metabolism.</p> Budesonide, Poorly water-soluble drugs, Self-nanoemulsifying drug delivery system, Oral delivery, Lymphatic absorption, Statistical optimization 24 32 http://ajpr1.umsha.ac.ir/browse.php?a_code=A-10-2-27&slc_lang=en&sid=1 Sahar Khoshyari 1003194753284600165 1003194753284600165 No Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran. Reza Mahjub r.mahjoub@umsha.ac.ir 1003194753284600166 1003194753284600166 Yes Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran.