en تخصصي Special كاربردي Applicable <span style="font-size:10pt"><span style="line-height:115%"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;">Global warming is increasingly affecting human health, with significant consequences for drug therapy. Rising temperatures and climate-related changes alter the pharmacokinetics and pharmacodynamics of medications, affecting their efficacy and safety. These changes may contribute to treatment failures, and may necessitate dose adjustments, especially in patients with chronic conditions such as heart failure and diabetes. Additionally, drug stability is compromised by higher ambient temperatures, increasing the risks of degradation and reduced therapeutic effectiveness. Vulnerable populations, including pediatric and elderly patients, face heightened risks due to impaired thermoregulation and heat intolerance. This article reviews the effects of climate change on drug therapy, emphasizing the need for healthcare systems to adapt their pharmaceutical care strategies in response to environmental changes. Understanding these shifts is critical to managing both emerging diseases and chronic health conditions in a warming world.</span></span></span><br> <br> &nbsp; Adverse Effects, Drug Therapy, Global Warming, Pharmacodynamics, Pharmacokinetics, Treatment Failure 116 122 http://ajpr.umsha.ac.ir/browse.php?a_code=A-10-2-93&slc_lang=en&sid=1 Nasibeh Ghalandari n.ghalandari@umsha.ac.ir No Hamadan University of Medical Sciences, Hamadan, Iran