en تخصصي Special پژوهشي Research <span style="font-size:10pt"><span style="line-height:115%"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span style="font-size:8.5pt"><span style="line-height:115%">Background:</span></span></b><span style="font-size:8.5pt"><span style="line-height:115%"> Repairing damaged bone tissue remains a major clinical challenge. Tissue engineering offers a promising solution, requiring scaffolds that support cell growth while delivering therapeutic molecules in a controlled manner. This study aimed to develop a novel composite scaffold for bone tissue engineering using a biodegradable polymer and drug-loaded metal-organic framework particles.</span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:115%"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span style="font-size:8.5pt"><span style="line-height:115%">Methods:</span></span></b><span style="font-size:8.5pt"><span style="line-height:115%"> We fabricated fibrous scaffolds via electrospinning using poly-L-lactic acid (PLLA) and iron-based metal-organic framework particles (Fe-MIL-88B-NH₂). The particles were functionalized with &beta;-cyclodextrin and loaded with the bone-active drug alendronate. The drug carrier was characterized using scanning electron microscopy (SEM), X-ray diffraction, and infrared spectroscopy. The loaded particles were then incorporated into the polymer solution to produce electrospun scaffolds. Drug release was evaluated in a simulated body fluid. Furthermore, human adipose-derived mesenchymal stem cells were cultured on the scaffolds, and their osteogenic behavior was assessed via alkaline phosphatase activity, calcium deposition, and MTT metabolic assays.</span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:115%"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span style="font-size:8.5pt"><span style="line-height:115%">Results:</span></span></b><span style="font-size:8.5pt"><span style="line-height:115%"> The drug carriers were successfully synthesized and characterized. The composite scaffolds released alendronate significantly slower than free drug carriers, demonstrating that the polymer network effectively controlled drug release over time. Biological assays revealed that scaffolds containing the drug-loaded particles were more effective than plain PLLA scaffolds in promoting bone-related cell activity and improving surface properties.</span></span></span></span></span><br> <span style="font-size:10pt"><span style="line-height:115%"><span style="font-family:&quot;Times New Roman&quot;,&quot;serif&quot;"><b><span style="font-size:8.5pt"><span style="line-height:115%">Conclusion:</span></span></b><span style="font-size:8.5pt"><span style="line-height:115%"> Combining the carrier system with alendronate in the electrospun PLLA matrix enhanced osteogenic activity, successfully driving stem cells toward bone-forming cells.</span></span></span></span></span><br> <br> &nbsp; Bone Tissue Engineering, Electrospinning, Metal-Organic Frameworks, Alendronate, Drug Delivery Systems. 88 98 http://ajpr.umsha.ac.ir/browse.php?a_code=A-10-2-89&slc_lang=en&sid=1 Azadeh Golmohamadpour No 1 College of Chemistry, Shahrood University of Technology, Shahrood, Iran Gebremariam Birhanu Wondie No Department of Pharmaceutics and Social Pharmacy, School of Pharmacy, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia Alireza Lotfabadi No 4 Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran Mehdi Doosti-Telgerd m-dusti@alumnus.tums.ac.ir Yes Department of Pharmaceutics, School of Pharmacy, Hamadan University of Medical Sciences, Hamadan, Iran