Hamadan University of Medical Sciences Avicenna Journal of Pharmaceutical Research 2717-1884 2 2 2021 12 30 The Genetic Basis of Hypertension: An Overview 91 98 10.34172/ajpr.2021.16 EN Arifa Sultana Ananya Saha Tahmina Akter Fahima Aktar Jakir Ahmed Chowdhury Abu Asad Chowdhury Shaila Kabir Md. Shah Amran REVIEW 10.34172/ajpr.2021.16 2021 12 07 2021 12 12 In light of the widespread recognition of the heritability of hypertension (HTN), numerous studies have been conducted to better understand the pathogenesis of different variants of HTN and their interactions. The complexity of crucial HTN makes it difficult to segregate and identify particular genes that influence blood pressure (BP) fluctuation, making the development of single-gene targeted treatments tough. Therefore, finding HTN susceptibility genes will contribute to the understanding of the biology behind the disease. Apart from its potential impact on antihypertensive drug therapy selection, genomic information may also contribute to identifying persons at risk of developing the condition, resulting in new preventative strategies. It is necessary to conduct more replication studies in other populations to confirm that there is a link between certain genetic variations and the varying response to these frequently used antihypertensive medications. Moreover, antihypertensive medication responsiveness to epigenetics and regulatory networks may be improved by further research. This may aid researchers to find new HTN therapeutic targets. This study aimed to come up with a list of known genetic variants that may play a role in HTN.