Hamadan University of Medical Sciences Avicenna Journal of Pharmaceutical Research 2717-1884 1 2 2020 12 31 Pulmonary Protective Effects of Propofol on Cisplatin-Induced Oxidative Damage in Male Rats 72 75 10.34172/ajpr.2020.13 EN Sajjad Makhdoomi https://orcid.org/0000-0002-4066-7040 Akram Oftade Sodabe Khodabandehlou Akram Ranjbar https://orcid.org/0000-0002-4564-3603 Journal Article 10.34172/ajpr.2020.13 2020 07 27 2020 09 13 Background: The present study was performed to investigate the protective effects of propofol against cisplatin-induced pulmonary toxicity in rats. Methods: A total of 20 male Wistar rats weighing 180-250 g were divided into four groups of control, the cisplatin-intoxicated group intraperitoneally (IP) injected with cisplatin (7 mg/kg/d for a week), the propofol group (10 mg/kg/d, IP), and the protected group receiving propofol (10 mg/kg/d, IP) poisoned by cisplatin. Then, the biomarkers of total antioxidant capacity (TAC), catalase (CAT) activity, and lipid peroxidation (LPO) were measured in homogeneous lung tissues. Results: The data revealed the evidence of oxidative stress in the lung tissue of cisplatin-intoxicated rats as indicated by an increase in the level of LPO compared with propofol and protected groups (P<0.05). Moreover, TAC decreased in the cisplatin group while it increased in the propofol group compared to cisplatin and protected groups (P<0.05). No significant difference was observed between the groups regarding CAT (P>0.05). Protection with propofol ameliorated the oxidative stress induced by cisplatin in the lung tissue because of the reduction of LPO. Conclusion: According to these results, it seems that propofol provides a remarkable protection against cisplatin-induced oxidative pulmonary damage mediated by its antioxidant properties.