Hamadan University of Medical Sciences Avicenna Journal of Pharmaceutical Research 2717-1884 1 1 2020 07 01 Supplement Therapy in Multiple Sclerosis: A Pharmacological View 37 45 10.34172/ajpr.2020.07 EN Mojdeh Mohammadi Seyedeh Anis Rashidizad Narges Lashkari Sara Ataei Rasool Haddadi Mohammad Mehdi Mahboobian REVIEW 10.34172/ajpr.2020.07 2020 03 03 2020 04 17 Natural products, herbal medicines, and supplements have received more attention of the scientific and pharmaceutical community. Supplemental and alternative medicines include dietary supplements, herbs, vitamins, minerals, and special diets. It has been found that some complementary and alternative medicines (CAMs) are safe and effective but the important point is that less is known about many of them. Medicines used in multiple sclerosis (MS) are not completely effective and various side effects have been detected. There is an increasing trend in the use of supplementary and alternative medicines in treating MS because of fewer side effects, more comfort, and more preventative effects. It has been indicated that up to 70%-80% of people with MS have tested herbal products or bioactive compounds for treating their disease. The present study aimed to investigate the use of natural products, herbal remedies, and supplements to treat MS to confirm or rule out the effectiveness or ineffectiveness of these supplementary medicines.