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Submitted: 01 Dec 2021
Accepted: 10 Dec 2021
ePublished: 30 Dec 2021
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Avicenna J Pharm Res. 2021;2: 79-90.
doi: 10.34172/ajpr.2021.15
  Abstract View: 34
  PDF Download: 27

Review Article

Hundred Years of Insulin: The Possibility of Development of Oral Dosage Form

Ananya Saha 1, Arifa Sultana 1, Fahmida Yesmin 1, Tahmina Akter 2, Al- Amin Sikder 1, Fahima Aktar 1, Jakir Ahmed Chowdhury 3, Abu Asad Chowdhury 1, Shaila Kabir 1, Md. Shah Amran 1*

1 Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
2 Department of Physiology, Dhaka Medical College, Dhaka 1000, Bangladesh
3 Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh
*Corresponding Author: Corresponding author: Md. Shah Amran,Molecular Pharmacology and Herbal Drug Research Laboratory, Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Dhaka, Dhaka-1000, Bangladesh Tel: +8801532603359 Email: , Email: amranms@du.ac.bd

Abstract

Diabetes is one of the major medical problems in the world. The discovery of insulin was a milestone in the history of medical science. This legendary invention has completed 100 years of its journey. Through this 100-year journey, many important events have taken place, and many modifications have been made to make it convenient for commercialization and patient compliance. After the antidiabetic activity of the pancreatic extract was discovered, the bovine and pork insulin came into use. Then, recombinant human insulin was discovered. Now long-acting to rapid-acting insulin forms are available (e.g., insulin pens, insulin pumps, and the like), and different systems are in use to deliver them to the body, but all these insulins are in invasive dosage forms and have some disadvantages, too. As we are using the oral form of most medicines, we prefer the oral form of insulin. Therefore, the concern is now to develop the oral dosage form of insulin. Some proposed oral dosage forms are at different stages of the clinical trial such as classical dosage forms, enzyme inhibitors, unnatural amino acids, nanoparticles, cell-penetrating peptides, and so on. Since the oral forms of insulin create some limitations and confusion, further research is required to solve these problems. Accordingly, the aim of the review was to predict the possibility of developing marketable oral insulin.
Keywords: Oral insulin, 100 years of insulin, Diabetes, Current forms of insulin, Pancreas, Recombinant technology

Please cite this article as follows: Saha A, Sultana A, Yesmin F, Akter T, Sikder AA, Aktar F, et al. Hundred years of insulin: the possibility of development of oral dosage form. Avicenna J Pharm Res. 2021; 2(2):79-90. doi:10.34172/ajpr.2021.15
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